Preheat oven to 350°F (175°C). Grease and line a loaf pan.
In a bowl, whisk together flour, baking soda, baking powder, pumpkin spice, and salt.
In another bowl, mix pumpkin purée, Greek yogurt, sugars, oil, eggs, and vanilla until smooth.
Gradually fold dry ingredients into wet ingredients until just combined (do not overmix).
Pour batter into the loaf pan and bake for 50–60 minutes, or until a toothpick comes out clean.
Cool in pan for 10 minutes, then transfer to a wire rack to cool completely before slicing.